Lipodystrophies: windows on adipose biology and metabolism
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چکیده
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منابع مشابه
Recombinant human leptin treatment in genetic lipodystrophic syndromes: the long-term Spanish experience
Lipodystrophies are a group of diseases mainly characterized by a loss of adipose tissue and frequently associated with insulin resistance, hypertriglyceridemia, and hepatic steatosis. In uncommon lipodystrophies, these complications frequently are difficult to control with conventional therapeutic approaches. This retrospective study addressed the effectiveness of recombinant methionyl leptin ...
متن کاملHuman lipodystrophies: genetic and acquired diseases of adipose tissue.
Human lipodystrophies represent a heterogeneous group of diseases characterized by generalized or partial fat loss, with fat hypertrophy in other depots when partial. Insulin resistance, dyslipidemia and diabetes are generally associated, leading to early complications. Genetic forms are uncommon: recessive generalized congenital lipodystrophies result in most cases from mutations in the genes ...
متن کاملLMNA-linked lipodystrophies: from altered fat distribution to cellular alterations.
Mutations in the LMNA gene, encoding the nuclear intermediate filaments the A-type lamins, result in a wide variety of diseases known as laminopathies. Some of them, such as familial partial lipodystrophy of Dunnigan and metabolic laminopathies, are characterized by lipodystrophic syndromes with altered fat distribution and severe metabolic alterations with insulin resistance and dyslipidaemia....
متن کاملLipodystrophy = الحثل الشحمي
The lipodystrophies are a heterogeneous group of diseases characterized by generalized or partial loss of subcutaneous fat. In addition to clearly exhibiting selective loss of adipose tissue, patients are also at risk for abnormalities such as insulin resistance, hyperinsulinemia, type 2 diabetes mellitus, hyperlipidemia, glomerulonephritis, and autoimmune disorders. Advances in molecular biolo...
متن کاملDiseases of adipose tissue: genetic and acquired lipodystrophies.
Human lipodystrophies represent a group of diseases characterized by altered body fat amount and/or repartition and major metabolic alterations with insulin resistance leading to diabetic complications and increased cardiovascular and hepatic risk. Genetic forms of lipodystrophies are rare. Congenital generalized lipodystrophy or Berardinelli-Seip syndrome, autosomal recessive, is characterized...
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